实验室乳化机如何进行中试放大？
发布日期：2024-01-17
阅读量：505
中间实验阶段是进一步研究工艺技术在特定规模装置中的各步变化规律，
会涉及到小试阶段无法发现和解决的问题，
工艺技术中每一步的最佳工艺条件可能会随着实验规模、设备等外部条件的变化而变化，
所以此阶段的重要性毋庸置疑。
中试放大不仅仅是规模扩大这么简单，
小试阶段主要任务是勘探开发，关注的是对所涉及材料的分析，以及反应、分离的过程，
而中试阶段要考虑的问题是如何在放大的同时保持物质、热量和动量等的平衡，
为实现具有工业意义和经济规模的生产提供稳定的工艺手段和可靠的数据依据。
实验室乳化机中试放大的方法如下：
1.经验放大法
根据经验通过逐步放大来探索反应器的特征，
从实验室装置到中间装置到中型装置最后到大型装置，
是原料药工艺放大研究最主要的方法。
经验放大法的前提是反应器必须保持与提供数据的装置完全相同的操作条件。
由于前提较难达到，所以放大倍数小，无法通过改变反应器结构或反应条件来优化反应器设计。
2.相似放大法
利用相似理论进行放大。
这种方法比较适合物理过程（搅拌器和传热装置）的放大。
缺点：无法保证几何、流体流动和传热传质都相似。
3.数学模拟放大法
应用计算机技术，是今后中试放大的主要发展方向。
优点：成本低，时间短，准确度高。
缺点：由于药物合成工艺太过复杂，无法对其构建较为完整的物理模型和数字模型。
4.微型中间装置
近年来微型中间装置发展迅速，采用微型中间装置替代大型中间装置，为工业化装置提供精确地设计数据。
其优点是成本低，施工速度快。
一般情况下，实验室到中试生产会采用较高的放大率，而中试到工业化生产则会采用较低的放大率。
这样可以提高工艺放大的成功率，减少潜在的风险和损失。
金宗MLR多功能实验室乳化机是我司技术人员采用德国技术，自行设计开发实验室乳化机，广泛在食品、制药、化妆品、化工、高校教学、各类研究所、技术研究院等。MLR标准系统的处理量有1L、2L、5L、10L等系列，均质机速度可达30000转，能在真空或压力环境下，实现物料的分散、乳化、均质、混合等工艺过程。可配备多种宏观搅拌器、高剪切均质乳化机以及可靠的真空密封系统和温控系统，多种传感检测系统能在实验室环境模拟工业化生产。
专栏：技术交流
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